Control and monitoring of temperature in the pharmaceutical supply chain

Many medicines can be destroyed by storage and transport at the wrong temperature. How proper monitoring solutions from ABB support best practice

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Chill out in the pharmaceutical supply chain

Almost one third of “critical and major deficiencies” uncovered in the storage and transport of medicines relate to the control and monitoring of temperature, according to the Medicines and Healthcare products Regulatory Agency (MHRA). The Agency reported that problems with temperature accounted for 30 percent of deficiencies, which is more than quality management failures (25 percent), documentation (24 percent), problems with premises or supply (8 percent each) and products (5 percent).

MHRA bases its guidance about storage and transportation on EU guidelines on Good Distribution Practice (GDP), which demand that distributors “ensure that storage conditions are observed at all times, including during transportation”. This not only applies to medicines that need to be stored at low temperatures (cold chain products) but also to medicines that should be stored below 25o or 30oC (temperate chain products). There is also a smaller but growing subset of products that need to be kept at sub-zero temperatures. And it’s not only high temperatures that can present a problem, when products such as vaccines, insulin, biotech products and blood products can all be denatured by freezing.

Following dispatch from a manufacturing facility, the distribution chain for medicines can be complex, potentially involving several storage facilities, wholesalers and modes of transport. Effective systems to measure and record the temperature at which products are held at every stage of their journey are therefore an important feature of systems designed to protect the quality of medicines ultimately administered to patients.

All distributors of medicinal products are required to record storage and transportation temperatures, as well as being licensed by the MHRA or their equivalent national regulatory body.

Storage requirements

For instance, storage facilities looking to handle significant volumes of high-risk cold chain products need specialist refrigeration capable of holding contents reliably at between 2°C and 8°C throughout the storage volume. As a minimum in small fridges, temperature monitoring should be performed by electronic max/min thermometers accurate to ±0.5°C. Continuous, independent, recording with alarms is also advisable. Probes should be placed within the load (or within a suitable buffer) so that they record the temperature of the products and not the air. Maximum and minimum temperatures should be logged daily. 

Larger refrigerators and walk-in cold rooms used in high-volume operations should be fitted with an electronic temperature-recording device that measures load temperatures. The chart, printout or direct reading should be checked and recorded daily. Paper records do the basic job, but it may be worth considering electronic recorders, which offer several advantages. 

For a start, videographic recorders can display multiple readings at a glance, making it much easier to keep track of installations that need to deploy a network of multiple temperature probes. The latest recorders also offer communications capabilities. For example, ABB units can be connected to wider control systems via Ethernet. This makes it easier to notify a central controller when a potential temperature problem triggers an alarm, or the system could be set up to send an SMS message to a responsible person so that remedial action can be taken right away. The third advantage is that electronic logging makes it easier to retrieve data days, weeks or even months later, making batch traceability much easier if a problem comes to light later on.
ABB has the knowledge and solutions to help you reach optimum temperature control throughout the pharmaceutical distribution chain.

Temperature mapping

Temperature mapping should be undertaken annually to ensure that regular readings accurately reflect the true temperature profile in the cold space. Extra surveys may also be needed to check everything is functioning well after alterations or maintenance work. 

Three probes might be enough to build up an accurate picture of small fridges, while 18 or more might be needed to map walk-in facilities. Surveys should also be carried out for at least 24 hours or however long it takes to give a fair reflection of the range of normal activities that take place within the facility, such as loading and unloading. Allow extra time on top for the temperature measurement equipment to stabilise. Anything unusual should be noted, such as loading with warm samples, for example, which can distort the results.

It’s pretty common for temperature mapping to uncover particular regions of the cold store that are warmer than others. If the top shelf of a fridge is too warm, for instance, it must not be used until remedial action can be taken and any high-risk products stored there will need to be quarantined.

Hitting the road

Transporting products between storage facilities can be thought of as an extension of storage activities. However, there are certain additional risks associated with being on the move. 

Anything from the time of year and the weather to the length of time a vehicle may be stuck in a traffic jam has the potential to impact on the effectiveness of temperature control measures in each journey. Every trip should therefore be treated as unique, rather than as a standard event that’s assumed to be successful provided certain standard procedures are followed. 

Cold chain products should be packed to ensure that the required temperatures are maintained throughout the journey. For example, insulated containers may be fine to protect small volumes of lower risk products with expected journey times of less than three hours. Gel or ice packs can be added for longer trips. However, larger volumes of higher-risk products will generally be shipped in refrigerated transport, especially if there’s a chance they could be held up. Whatever method of transport is used, it is important to show that the required temperatures can be maintained throughout the trip, so wholesalers should validate their temperature controls using temperature loggers.

The number of temperature monitors will depend on the size of the load and they must be located to ensure that temperatures in all parts of the load remain acceptable, especially since the temperature gradient within a large load can vary significantly from the edge to the middle. 

If temperature-stabilising materials are used they must be chosen carefully. For example, dry ice should not be used when shipping rubber-stoppered vials because the excessively low temperature can shrink the rubber. 

Like the static storage facilities, refrigerated vehicles handling high-risk products should be fitted with continuous recording devices and transporters should provide a clear diary of each journey.
Like the static storage facilities, refrigerated vehicles handling high-risk products should be fitted with continuous recording devices and transporters should provide a clear diary of each journey.

Connecting the links

Pick-ups and deliveries present a special risk throughout the supply chain. Suppliers should indicate clearly on the packaging both when any temperature-controlled products were removed from cold storage and when they must be put back. At the other end, distributors should make recipients aware of any goods that require special storage conditions. The recipient should also check that the medicines have been properly protected during their journey, for instance, by checking a recording device. 

Of course, having a proper log of temperatures is only useful if distributors review them and have effective procedures in place to take corrective action if there’s a problem. GDP inspectors working for the MHRA have reported some appalling instances of bad practice, such as no temperature monitoring in some facilities or alarms being ignored over the weekend as the temperature of a cold store continues to climb. The monitoring technology is there to support good practice, but success will ultimately depend on developing a culture of responsibility throughout the entire supply chain.
Best-Practice Guide: pharmaceutical-chain temperature control and recording

These are just some of the key factors that need to be considered. As a responsible and experienced supplier of temperature mapping and calibration services, ABB gives you everything you need to meet MHRA expectations.

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          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Energy Efficiency",
      "Value": "3"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Enterprise Asset Management",
      "Value": "4"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Enterprise Connectivity",
      "Value": "5"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Information Management",
      "Value": "6"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Integrated Safety",
      "Value": "7"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Operator Effectiveness",
      "Value": "8"
    },
    {
      "Attributes": {
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        "CssStyle": {
          "Keys": [],
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Service",
      "Value": "13"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Simulation",
      "Value": "9"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Sustainable Solutions",
      "Value": "10"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "System Evolution",
      "Value": "11"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Virtualization",
      "Value": "12"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Primary metals",
      "Value": "15"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Hot rolling",
      "Value": "16"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Cold rolling",
      "Value": "17"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Processing lines",
      "Value": "18"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Quality",
      "Value": "19"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Metallurgy",
      "Value": "20"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Electromagnetic stirring",
      "Value": "21"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "EMS ",
      "Value": "22"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Stockyard ",
      "Value": "23"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Blast furnace ",
      "Value": "24"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Ironmaking ",
      "Value": "25"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Electric arc furnace ",
      "Value": "26"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Ladle furnace ",
      "Value": "27"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Aluminium furnace ",
      "Value": "28"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Thick slab casting ",
      "Value": "29"
    },
    {
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        "CssStyle": {
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          "Value": null
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      "Enabled": true,
      "Selected": false,
      "Text": "Thin slab casting",
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        "CssStyle": {
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Digitalization ",
      "Value": "31"
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};
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  "Name": "Country",
  "Label": "",
  "Hint": "",
  "Preselected": "",
  "Excluded": [],
  "Custom": [],
  "Order": {},
  "Placeholder": "All",
  "Multiple": 0
};
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  "FieldName": "Country",
  "FieldType": "Choices",
  "RepresentationType": "SingleSelect",
  "RepresentationConfigs": [
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      "ObjectType": "Radio",
      "Name": "Country",
      "Label": "",
      "Hint": "",
      "Preselected": "",
      "Excluded": [],
      "Custom": [],
      "Order": {},
      "Placeholder": ""
    },
    {
      "ObjectType": "SingleSelect",
      "Name": "Country",
      "Label": "",
      "Hint": "",
      "Preselected": "",
      "Excluded": [],
      "Custom": [],
      "Order": {},
      "Placeholder": "All",
      "Multiple": 0
    }
  ],
  "DisplayOrder": "4",
  "ItemsCollection": [
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Argentina",
      "Value": "14"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Australia",
      "Value": "15"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Austria",
      "Value": "49"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Belgium",
      "Value": "16"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Brazil",
      "Value": "1"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Bolivia",
      "Value": "17"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Bulgaria",
      "Value": "2"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Canada",
      "Value": "18"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Chile",
      "Value": "19"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "China",
      "Value": "3"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Colombia",
      "Value": "20"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Czech Republic",
      "Value": "47"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Denmark",
      "Value": "21"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Egypt",
      "Value": "22"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Finland",
      "Value": "23"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "France",
      "Value": "24"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Germany",
      "Value": "4"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Hungary",
      "Value": "25"
    },
    {
      "Attributes": {
        "Keys": [],
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        "CssStyle": {
          "Keys": [],
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Iceland",
      "Value": "26"
    },
    {
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        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "India",
      "Value": "27"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
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          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Indonesia",
      "Value": "28"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Iraq",
      "Value": "5"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Ireland",
      "Value": "45"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Italy",
      "Value": "29"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Kazakhstan",
      "Value": "48"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Malaysia",
      "Value": "30"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "New Caledonia",
      "Value": "31"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Netherlands",
      "Value": "32"
    },
    {
      "Attributes": {
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        "CssStyle": {
          "Keys": [],
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          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "New Zealand",
      "Value": "33"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Norway",
      "Value": "34"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Oman",
      "Value": "35"
    },
    {
      "Attributes": {
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        "CssStyle": {
          "Keys": [],
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          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Pakistan",
      "Value": "46"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Peru",
      "Value": "36"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Poland",
      "Value": "6"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Qatar",
      "Value": "37"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Romania",
      "Value": "51"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Russia",
      "Value": "38"
    },
    {
      "Attributes": {
        "Keys": [],
        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Saudi Arabia",
      "Value": "39"
    },
    {
      "Attributes": {
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        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Singapore",
      "Value": "40"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
          "Keys": [],
          "Count": 0,
          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Slovenia",
      "Value": "53"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
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          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "South Africa",
      "Value": "7"
    },
    {
      "Attributes": {
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        "CssStyle": {
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Spain",
      "Value": "41"
    },
    {
      "Attributes": {
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        "CssStyle": {
          "Keys": [],
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        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Sri Lanka",
      "Value": "8"
    },
    {
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        "CssStyle": {
          "Keys": [],
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Sweden",
      "Value": "9"
    },
    {
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        "CssStyle": {
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          "Value": null
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Switzerland",
      "Value": "42"
    },
    {
      "Attributes": {
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        "CssStyle": {
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      },
      "Enabled": true,
      "Selected": false,
      "Text": "Thailand",
      "Value": "10"
    },
    {
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        "CssStyle": {
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          "Value": null
        }
      },
      "Enabled": true,
      "Selected": false,
      "Text": "Turkey",
      "Value": "50"
    },
    {
      "Attributes": {
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        "Count": 0,
        "CssStyle": {
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Search criteria provided no results

There are There is 1 results listed below result listed below 

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Select region / language